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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621109 Species: Rattus norvegicus RGD Object: Gene Symbol: Psmd4 Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

Acc ID: CHEBI:32509 Term: pirinixic acid Definition: An aryl sulfide that has formula C14H14ClN3O2S. CasRN: 50892-23-4 Chemical ID: MESH:C006253

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:734298	6480464	CTD	pirinixic acid results in increased expression of PSMD4 mRNA	PMID:17426115 PMID:18301758 PMID:20059764 PMID:15375163
multiple interactions	ISO	RGD:734298	6480464	CTD	PPARA protein promotes the reaction [pirinixic acid results in increased expression of PSMD4 mRNA]	PMID:20059764
affects expression	EXP		6480464	CTD	pirinixic acid affects the expression of PSMD4 mRNA	PMID:19483382
increases expression	ISO	RGD:734298	6480464	CTD	pirinixic acid results in increased expression of PSMD4 mRNA	PMID:18301758 PMID:15375163 PMID:20059764 PMID:17426115
increases expression	ISO	RGD:734298	6480464	CTD	pirinixic acid results in increased expression of PSMD4 mRNA	PMID:15375163 PMID:17426115 PMID:20059764 PMID:18301758
increases expression	ISO	RGD:734298	6480464	CTD	pirinixic acid results in increased expression of PSMD4 mRNA	PMID:15375163 PMID:21318169 PMID:18301758 PMID:20059764 PMID:17426115
multiple interactions	ISO	RGD:734298	6480464	CTD	PPARA protein affects the reaction [pirinixic acid results in increased expression of PSMD4 mRNA]	PMID:21318169
increases expression	ISO	RGD:734298	6480464	CTD	pirinixic acid results in increased expression of PSMD4 mRNA	PMID:17426115 PMID:21318169 PMID:20059764 PMID:15375163 PMID:18301758
increases expression	ISO	RGD:734298	6480464	CTD	pirinixic acid results in increased expression of PSMD4 mRNA	PMID:20059764 PMID:21318169 PMID:17426115 PMID:15375163 PMID:18301758
increases expression	ISO	RGD:734298	6480464	CTD	pirinixic acid results in increased expression of PSMD4 mRNA	PMID:15375163 PMID:17426115 PMID:18301758 PMID:20059764 PMID:21318169