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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109 Species: Mus musculus RGD Object: Gene Symbol: Col1a1 Name: collagen, type I, alpha 1

Acc ID: CHEBI:16643 Term: L-methionine Definition: The L-enantiomer of methionine. CasRN: 63-68-3 Chemical ID: MESH:D008715

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA] NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]] pirinixic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]	PMID:19593819
multiple interactions	ISO	RGD:61817	6480464	CTD	Methionine inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]	PMID:15158331
multiple interactions	EXP		6480464	CTD	Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of COL1A1 mRNA]	PMID:18513333
multiple interactions	EXP		6480464	CTD	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL1A1 mRNA	PMID:20938992
multiple interactions	EXP		6480464	CTD	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL1A1 mRNA	PMID:20548288 PMID:20938992
multiple interactions	EXP		6480464	CTD	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA	PMID:19593819 PMID:20697377
multiple interactions	EXP		6480464	CTD	CCL2 protein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]	PMID:20697377