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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of and affects the localization of DNMT1 proteinPMID:21163286
Dnmt1decreases expressionISODnmt1 (Mus musculus)6480464CTDDiethylnitrosamine results in decreased expression of DNMT1 mRNAPMID:19996281
Dnmt1increases expressionISODnmt1 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of DNMT1 mRNAPMID:17854601
Dnmt1multiple interactionsISODnmt1 (Mus musculus)6480464CTDAHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DNMT1 mRNA]; RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DNMT1 mRNA]PMID:17854601 PMID:19996281
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