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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620979
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt1
Name: DNA methyltransferase 1
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt1multiple interactionsEXP 6480464CTD[Testosterone co-treated with vinclozolin] results in increased expression of DNMT1 mRNA; Testosterone inhibits the reaction [vinclozolin results in decreased expression of DNMT1 mRNA]PMID:20056826
Dnmt1decreases expressionISODNMT1 (Homo sapiens)6480464CTDTestosterone results in decreased expression of DNMT1 mRNAPMID:21592394
Dnmt1multiple interactionsISODNMT1 (Homo sapiens)6480464CTD[Testosterone co-treated with Calcitriol] results in decreased expression of DNMT1 mRNAPMID:21592394
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