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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620966
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Acc ID: CHEBI:17967
Term: urethane
Definition: A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages.
Chemical ID: MESH:D014520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k1decreases expressionISOMAP3K1 (Homo sapiens)6480464CTDUrethane results in decreased expression of MAP3K1 mRNAPMID:28818685
Map3k1multiple interactionsISOMap3k1 (Mus musculus)6480464CTD[Urethane co-treated with Freund's Adjuvant] results in increased expression of MAP3K1 mRNA; tocopheryloxybutyric acid inhibits the reaction [Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein]; Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein; Vitamin E inhibits the reaction [Urethane results in increased phosphorylation of and results in increased activity of MAP3K1 protein]PMID:11062179 PMID:12400877
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