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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620955
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lss
Name: lanosterol synthase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lssaffects expressionEXP 6480464CTDbisphenol A affects the expression of LSS mRNAPMID:32145629
Lssdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of LSS mRNAPMID:25181051 PMID:30816183
Lssincreases expressionEXP 6480464CTDbisphenol A results in increased expression of LSS mRNAPMID:31771501
Lssincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of LSS genePMID:28505145
Lssaffects expressionISOLSS (Homo sapiens)6480464CTDbisphenol A affects the expression of LSS mRNAPMID:30903817
Lssdecreases expressionISOLSS (Homo sapiens)6480464CTDbisphenol A results in decreased expression of LSS proteinPMID:37567409
Lssincreases expressionISOLss (Mus musculus)6480464CTDbisphenol A results in increased expression of LSS mRNAPMID:21932408 PMID:25168180 PMID:25270620
Lssincreases expressionISOLSS (Homo sapiens)6480464CTDbisphenol A results in increased expression of LSS mRNA; bisphenol A results in increased expression of LSS proteinPMID:29275510 PMID:34186270
Lssmultiple interactionsISOLss (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of LSS mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of LSS mRNAPMID:28433925 PMID:35739755
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