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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620944
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp7
Name: caspase 7
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp7increases activityISOCASP7 (Homo sapiens)6480464CTDsorafenib results in increased activity of CASP7 proteinPMID:19770576 PMID:20054642
Casp7multiple interactionsISOCASP7 (Homo sapiens)6480464CTD[sorafenib co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP7 protein; sorafenib results in increased cleavage of and results in increased activity of CASP7 proteinPMID:16109713 PMID:17909059
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