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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620944
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp7
Name: caspase 7
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp7increases activityISOCASP7 (Homo sapiens)6480464CTDPaclitaxel results in increased activity of CASP7 proteinPMID:22302033
Casp7increases cleavageISOCASP7 (Homo sapiens)6480464CTDPaclitaxel results in increased cleavage of CASP7 proteinPMID:27664577
Casp7increases expressionISOCASP7 (Homo sapiens)6480464CTDPaclitaxel results in increased expression of CASP7 mRNA; Paclitaxel results in increased expression of CASP7 proteinPMID:18058816 PMID:31433962 PMID:31628941
Casp7multiple interactionsISOCASP7 (Homo sapiens)6480464CTD[Calcitriol co-treated with Curcumin] promotes the reaction [Paclitaxel results in increased expression of CASP7 protein]; [Doxorubicin co-treated with Paclitaxel co-treated with Fluorouracil] results in increased activity of CASP7 protein; [Resveratrol co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of CASP7 protein; [Sirolimus co-treated with Paclitaxel] results in increased cleavage of CASP7 protein; Calcitriol inhibits the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; Curcumin inhibits the reaction [Calcitriol inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of CASP7 protein]; palbociclib inhibits the reaction [Paclitaxel results in increased activity of CASP7 protein]PMID:14749477 PMID:15753396 PMID:16168113 PMID:22302033 PMID:31628941
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