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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620944
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp7
Name: caspase 7
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp7increases expressionISOCasp7 (Mus musculus)6480464CTDMercuric Chloride results in increased expression of CASP7 mRNAPMID:23202902
Casp7multiple interactionsISOCasp7 (Mus musculus)6480464CTD[Mercuric Chloride co-treated with prolinedithiocarbamate] results in increased degradation of CASP7 protein; Acetylcysteine inhibits the reaction [[Mercuric Chloride co-treated with prolinedithiocarbamate] results in increased degradation of CASP7 protein]PMID:22909951
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