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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620944 Species: Rattus norvegicus RGD Object: Gene Symbol: Casp7 Name: caspase 7

Acc ID: CHEBI:28939 Term: N-acetyl-L-cysteine Definition: The N-acetylated derivative of natural amino acid L-cysteine. CasRN: 616-91-1 Chemical ID: MESH:D000111

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1298347	6480464	CTD	Acetylcysteine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of and results in increased cleavage of CASP7 protein] Acetylcysteine inhibits the reaction [Dopamine results in increased activity of and results in increased cleavage of CASP7 protein] Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of and results in increased cleavage of CASP7 protein] Acetylcysteine inhibits the reaction [Isoproterenol results in increased activity of and results in increased cleavage of CASP7 protein]	PMID:17136323
multiple interactions	ISO	RGD:1298347	6480464	CTD	Acetylcysteine inhibits the reaction [arsenic trioxide results in increased activity of CASP7 protein]	PMID:19771260
multiple interactions	ISO	RGD:1298347	6480464	CTD	Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein]	PMID:21843585
multiple interactions	ISO	RGD:1553182	6480464	CTD	Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of CASP7 mRNA]	PMID:21549813
multiple interactions	EXP		6480464	CTD	Acetylcysteine inhibits the reaction [arsenic trioxide results in increased activity of CASP7 protein]	PMID:21145380
multiple interactions	ISO	RGD:1298347	6480464	CTD	Acetylcysteine inhibits the reaction [fucoxanthin results in increased cleavage of CASP7 protein]	PMID:20594983
multiple interactions	EXP		6480464	CTD	Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased cleavage of CASP7 protein]	PMID:22085843
multiple interactions	ISO	RGD:1298347	6480464	CTD	Acetylcysteine inhibits the reaction [arsenite results in increased activity of CASP7 protein]	PMID:22260869
multiple interactions	ISO	RGD:1553182	6480464	CTD	Acetylcysteine inhibits the reaction [[Mercuric Chloride co-treated with prolinedithiocarbamate] results in increased degradation of CASP7 protein]	PMID:22909951