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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620899
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pik3c3
Name: phosphatidylinositol 3-kinase, catalytic subunit type 3
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3c3multiple interactionsISOPIK3C3 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [Hydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; [3-methyladenine results in decreased activity of PIK3C3 protein] which results in decreased susceptibility to Hydrogen Peroxide; Hydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]; PIK3C3 protein promotes the reaction [Hydrogen Peroxide results in increased activity of BAX protein]PMID:20525898 PMID:21742779
Pik3c3multiple interactionsISOPik3c3 (Mus musculus)6480464CTD[Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of PIK3C3 mRNAPMID:27057282
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