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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620893
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaa2
Name: protein kinase AMP-activated catalytic subunit alpha 2
Acc ID: CHEBI:18406
Term: AICA ribonucleotide
Definition: A 1-(phosphoribosyl)imidazolecarboxamide that is acadesine in which the hydroxy group at the 5' position has been converted to its monophosphate derivative.
Chemical ID: MESH:C031143
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkaa2multiple interactionsEXP 6480464CTDPRKAA2 protein promotes the reaction [AICA ribonucleotide promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]]PMID:22815988
Prkaa2increases phosphorylationISOPRKAA2 (Homo sapiens)6480464CTDAICA ribonucleotide results in increased phosphorylation of PRKAA2 proteinPMID:18482975
Prkaa2multiple interactionsISOPRKAA2 (Homo sapiens)6480464CTDAICA ribonucleotide results in increased phosphorylation of and results in increased activity of PRKAA2 protein; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CYP4F2 mRNA]PMID:16873680 PMID:21205922
Prkaa2multiple interactionsISOPrkaa2 (Mus musculus)6480464CTDPRKAA2 protein affects the reaction [AICA ribonucleotide inhibits the reaction [AKT1 protein mutant form affects the susceptibility to Glucose deficiency]]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 mRNA]; PRKAA2 protein affects the reaction [AICA ribonucleotide results in increased expression of CTNNB1 protein]PMID:15806154 PMID:21454484
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