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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620798
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mtnr1b
Name: melatonin receptor 1B
Acc ID: CHEBI:131788
Term: luzindole
Definition: A member of the class of indoles that is tryptamine in which one of the amino hydrogens is replaced by an acetyl group while the hydrogen at position 2 is replaced by a benzyl group.
Chemical ID: MESH:C057154
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mtnr1bmultiple interactionsEXP 6480464CTDluzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]PMID:28238930
Mtnr1bmultiple interactionsISOMtnr1b (Mus musculus)6480464CTD[luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin; luzindole binds to and results in decreased activity of MTNR1B proteinPMID:11270484 PMID:21473625
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