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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620786
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Msh2
Name: mutS homolog 2
Acc ID: CHEBI:60761
Term: floxuridine
Definition: A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Chemical ID: MESH:D005467
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Msh2decreases response to substanceISOMSH2 (Homo sapiens)6480464CTDMSH2 protein results in decreased susceptibility to FloxuridinePMID:22194930
Msh2multiple interactionsISOMSH2 (Homo sapiens)6480464CTDolaparib inhibits the reaction [MSH2 protein results in decreased susceptibility to Floxuridine]PMID:22194930
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