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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620786
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Msh2
Name: mutS homolog 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Msh2decreases expressionEXP 6480464CTDCisplatin results in decreased expression of MSH2 mRNAPMID:18172885
Msh2affects response to substanceISOMsh2 (Mus musculus)6480464CTDMSH2 affects the susceptibility to Cisplatin; MSH2 protein affects the susceptibility to CisplatinPMID:12185594 PMID:21667017
Msh2decreases expressionISOMSH2 (Homo sapiens)6480464CTDCisplatin results in decreased expression of MSH2 proteinPMID:21696631
Msh2increases expressionISOMSH2 (Homo sapiens)6480464CTDCisplatin results in increased expression of MSH2 mRNAPMID:27594783
Msh2increases response to substanceISOMSH2 (Homo sapiens)6480464CTDMSH2 protein results in increased susceptibility to CisplatinPMID:21285353
Msh2increases response to substanceISOMsh2 (Mus musculus)6480464CTDMSH2 protein results in increased susceptibility to CisplatinPMID:21285353
Msh2multiple interactionsISOMSH2 (Homo sapiens)6480464CTD[Estradiol results in increased expression of MSH2 mRNA] which results in increased susceptibility to Cisplatin; Cisplatin promotes the reaction [MSH2 protein binds to and affects the localization of ATR protein]; MSH2 protein promotes the reaction [Cisplatin results in increased expression of BBC3 protein]; MSH2 protein promotes the reaction [Cisplatin results in increased phosphorylation of CHEK2 protein]; MSH2 protein promotes the reaction [Cisplatin results in increased phosphorylation of TP53 protein]; sodium arsenite inhibits the reaction [Cisplatin results in decreased expression of MSH2 protein]PMID:21285353 PMID:21696631 PMID:28323900
Msh2multiple interactionsISOMsh2 (Mus musculus)6480464CTDMSH2 protein promotes the reaction [Cisplatin results in increased expression of BBC3 protein]; MSH2 protein promotes the reaction [Cisplatin results in increased phosphorylation of CHEK2 protein]; MSH2 protein promotes the reaction [Cisplatin results in increased phosphorylation of TRP53 protein]PMID:21285353
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