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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620766 Species: Rattus norvegicus RGD Object: Gene Symbol: Tmprss2 Name: transmembrane protease, serine 2

Acc ID: CHEBI:16330 Term: 17beta-hydroxy-5alpha-androstan-3-one Definition: An androgen that has formula C19H30O2. CasRN: 521-18-6 Chemical ID: MESH:D013196

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1354092	6480464	CTD	Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [AR protein binds to TMPRSS2 enhancer]] Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [FOXA1 protein binds to TMPRSS2 enhancer]] Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [GATA2 protein binds to TMPRSS2 enhancer]]	PMID:22258452
multiple interactions	ISO	RGD:1354092	6480464	CTD	Etoposide inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA] merbarone inhibits the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA] TOP2B protein promotes the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]	PMID:20601956
decreases expression	ISO	RGD:1354092	6480464	CTD	Dihydrotestosterone results in decreased expression of TMPRSS2 mRNA	PMID:12711008
increases expression	ISO	RGD:1354092	6480464	CTD	Dihydrotestosterone results in increased expression of TMPRSS2 mRNA	PMID:20601956