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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620588
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd14
Name: CD14 molecule
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd14affects bindingEXP 6480464CTDLipopolysaccharides binds to CD14 proteinPMID:11343695
Cd14increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CD14 mRNA; Lipopolysaccharides results in increased expression of CD14 proteinPMID:16309824 PMID:18710323 PMID:21846543
Cd14multiple interactionsEXP 6480464CTDCD14 protein affects the reaction [Lipopolysaccharides results in increased secretion of Nitric Oxide]; CD14 protein promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of NOS2 protein]; CD14 protein promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Tretinoin promotes the reaction [Lipopolysaccharides results in increased expression of CD14 mRNA]PMID:12133974 PMID:16309824 PMID:16651628
Cd14affects response to substanceISOCd14 (Mus musculus)6480464CTDCD14 protein affects the susceptibility to LipopolysaccharidesPMID:11581577
Cd14decreases expressionISOCD14 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of CD14 mRNA; Lipopolysaccharides results in decreased expression of CD14 proteinPMID:18390722 PMID:35811015
Cd14decreases expressionISOCd14 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of CD14 mRNAPMID:12057914
Cd14increases expressionISOCD14 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CD14 mRNA; Lipopolysaccharides results in increased expression of CD14 proteinPMID:12176910 PMID:18180316 PMID:31935363
Cd14increases expressionISOCd14 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of CD14 mRNA; Lipopolysaccharides results in increased expression of CD14 proteinPMID:10223745 PMID:10975854 PMID:12057914 PMID:19136613 PMID:22445859 PMID:22687549 PMID:23182953 PMID:26141388 PMID:27339419
Cd14increases localizationISOCd14 (Mus musculus)6480464CTDLipopolysaccharides results in increased localization of CD14 proteinPMID:21276822
Cd14increases response to substanceISOCd14 (Mus musculus)6480464CTDCD14 protein results in increased susceptibility to LipopolysaccharidesPMID:21266194
Cd14multiple interactionsISOCD14 (Homo sapiens)6480464CTD2,5-dimethyl-4-benzoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]; 2-tert-butyl-4-quinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]; [alfacalcidol co-treated with Lipopolysaccharides] results in increased expression of CD14 protein; [LY96 protein results in increased expression of CD14 mRNA] which results in increased susceptibility to Lipopolysaccharides; [Resveratrol co-treated with Lipopolysaccharides] results in increased expression of CD14 protein; [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CD14 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of CD14 mRNA; BAY 11-7085 inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]; CD14 protein affects the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]; Curcumin inhibits the reaction [Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]; Glucose promotes the reaction [Lipopolysaccharides results in increased expression of CD14 protein]; phenylbenzoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]PMID:15135313 PMID:15946915 PMID:18180316 PMID:20700758 PMID:31935363 PMID:35811015
Cd14multiple interactionsISOCd14 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 mRNA]; 2,4,5,2',5'-pentachlorobiphenyl inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 mRNA]; [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 2,4,5,2',5'-pentachlorobiphenyl] inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 mRNA]; [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 mRNA]; [2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 mRNA]; [2,4,5,2',5'-pentachlorobiphenyl co-treated with PCB 180] inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 mRNA]; [Aflatoxin B1 co-treated with aflatoxin B2] inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 protein]; [CD14 protein results in increased susceptibility to Lipopolysaccharides] which affects the susceptibility to Ethanol; [Lipopolysaccharides co-treated with CD14 protein] results in increased phosphorylation of RELA protein; [Lipopolysaccharides co-treated with CD14 protein] results in increased secretion of IL6 protein; CD14 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]; CD14 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; CD14 protein affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; CD14 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; CD14 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; CD14 protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; genipin inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 mRNA]; glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt inhibits the reaction [Lipopolysaccharides results in increased localization of CD14 protein]; Lipopolysaccharides promotes the reaction [LPAR1 protein binds to CD14 protein]; methyl-beta-cyclodextrin inhibits the reaction [Lipopolysaccharides promotes the reaction [LPAR1 protein binds to CD14 protein]]; PCB 180 inhibits the reaction [Lipopolysaccharides results in increased expression of CD14 mRNA]PMID:11123339 PMID:21266194 PMID:21276822 PMID:21821728 PMID:22445859 PMID:22687549 PMID:26141388 PMID:28411859
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