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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620574
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cybb
Name: cytochrome b-245 beta chain
Acc ID: CHEBI:81520
Term: 2,3',4,4',5-Pentachlorobiphenyl
Definition: A pentachlorobiphenyl that has formula C12H5Cl5.
Chemical ID: MESH:C070055
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cybbincreases expressionISOCYBB (Homo sapiens)6480464CTD2,3',4,4',5-pentachlorobiphenyl results in increased expression of CYBB mRNAPMID:31251971
Cybbmultiple interactionsISOCYBB (Homo sapiens)6480464CTD2,3',4,4',5-pentachlorobiphenyl promotes the reaction [NCF1 protein binds to CYBB protein]; 2,3',4,4',5-pentachlorobiphenyl promotes the reaction [NCF1 protein modified form binds to CYBB protein]; AHR protein affects the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of CYBB mRNA]PMID:20299304 PMID:31251971
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