Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620574
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cybb
Name: cytochrome b-245 beta chain
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cybbaffects response to substanceISOCybb (Mus musculus)6480464CTDCYBB protein affects the susceptibility to Folic Acid deficiencyPMID:20116427
Cybbincreases response to substanceISOCybb (Mus musculus)6480464CTDCYBB results in increased susceptibility to Folic AcidPMID:21647593
Cybbmultiple interactionsISOCybb (Mus musculus)6480464CTDCYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [Folic Acid deficiency results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [Folic Acid deficiency results in decreased expression of NPHS2 protein]; CYBB mutant form inhibits the reaction [Folic Acid deficiency results in increased expression of ACTA2 protein]; CYBB mutant form inhibits the reaction [Folic Acid deficiency results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [Folic Acid deficiency results in increased secretion of ALB protein]; CYBB protein affects the reaction [Folic Acid deficiency results in increased chemical synthesis of Superoxides]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS1 mRNA]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA]; Folic Acid inhibits the reaction [AGT protein results in increased expression of CYBB protein]PMID:20116427 PMID:21647593 PMID:24386282
Go Back to source page   Continue to Ontology report