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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620574
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cybb
Name: cytochrome b-245 beta chain
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cybbincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CYBB protein; Lipopolysaccharides results in increased expression of NOX2 proteinPMID:17448908 PMID:31707400
Cybbmultiple interactionsEXP 6480464CTDalisol B 23-acetate inhibits the reaction [Lipopolysaccharides results in increased expression of NOX2 protein]PMID:31707400
Cybbincreases activityISOCybb (Mus musculus)6480464CTDLipopolysaccharides results in increased activity of CYBB proteinPMID:19005069
Cybbincreases expressionISOCYBB (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CYBB mRNA; Lipopolysaccharides results in increased expression of CYBB proteinPMID:17855475 PMID:24835767
Cybbincreases expressionISOCybb (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of CYBB mRNA; Lipopolysaccharides results in increased expression of CYBB protein; Lipopolysaccharides results in increased expression of NOX2 proteinPMID:15795323 PMID:17855475 PMID:24835767 PMID:27339419 PMID:27568862 PMID:31707400
Cybbmultiple interactionsISOCYBB (Homo sapiens)6480464CTDCAV1 mutant form promotes the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]; CYBB mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB protein]PMID:17855475 PMID:24835767 PMID:24967690
Cybbmultiple interactionsISOCybb (Mus musculus)6480464CTDalisol B 23-acetate inhibits the reaction [Lipopolysaccharides results in increased expression of NOX2 protein]; CAV1 gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]; CAV1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]; coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]; CYBB protein affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; CYBB protein affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB mRNA]; N-(4-O-glycerol-3-methoxybenzyl)nonivamide inhibits the reaction [Lipopolysaccharides results in increased expression of CYBB protein]PMID:15795323 PMID:17855475 PMID:24835767 PMID:27568862 PMID:31707400
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