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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620563
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lpar1
Name: lysophosphatidic acid receptor 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lpar1decreases expressionEXP 6480464CTDValproic Acid results in decreased expression of LPAR1 mRNAPMID:33150595
Lpar1increases expressionEXP 6480464CTDValproic Acid results in increased expression of LPAR1 mRNAPMID:23665938
Lpar1increases methylationEXP 6480464CTDValproic Acid results in increased methylation of LPAR1 promoterPMID:33150595
Lpar1affects expressionISOLPAR1 (Homo sapiens)6480464CTDValproic Acid affects the expression of LPAR1 mRNAPMID:25979313
Lpar1decreases expressionISOLPAR1 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of LPAR1 mRNAPMID:23179753 PMID:24383497 PMID:26272509 PMID:27188386 PMID:28001369
Lpar1increases expressionISOLPAR1 (Homo sapiens)6480464CTDValproic Acid results in increased expression of LPAR1 mRNAPMID:19101580
Lpar1increases expressionISOLpar1 (Mus musculus)6480464CTDValproic Acid results in increased expression of LPAR1 mRNAPMID:19136453 PMID:24896083
Lpar1multiple interactionsISOLPAR1 (Homo sapiens)6480464CTD[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LPAR1 mRNAPMID:27188386
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