GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mcl1 | affects expression | ISO | MCL1 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the expression of MCL1 mRNA | PMID:22046442 | Mcl1 | decreases expression | ISO | MCL1 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MCL1 protein | PMID:17148679 PMID:23353698 | Mcl1 | increases degradation | ISO | MCL1 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of MCL1 protein | PMID:21821001 | Mcl1 | multiple interactions | ISO | MCL1 (Homo sapiens) | 6480464 | CTD | [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in decreased expression of MCL1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of MCL1 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of MCL1 protein; LGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of MCL1 protein] | PMID:20856197 PMID:21821001 PMID:22046442 | | ||||||||||||||||||||||
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