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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620525
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mcl1
Name: MCL1 apoptosis regulator, BCL2 family member
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mcl1decreases expressionISOMCL1 (Homo sapiens)6480464CTDepigallocatechin gallate analog results in decreased expression of MCL1 proteinPMID:16115949
Mcl1multiple interactionsISOMCL1 (Homo sapiens)6480464CTD[Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of MCL1 mRNA alternative form; [Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of MCL1 mRNA alternative form; calyculin A inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of MCL1 mRNA alternative form]; calyculin A inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of MCL1 mRNA alternative form]; CAT protein inhibits the reaction [epigallocatechin gallate analog results in decreased expression of MCL1 protein]; tautomycin inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of MCL1 mRNA alternative form]; tautomycin inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of MCL1 mRNA alternative form]PMID:16115949 PMID:18348186
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