GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mcl1 | decreases expression | ISO | MCL1 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of MCL1 protein | PMID:17935137 PMID:20856197 | Mcl1 | decreases response to substance | ISO | MCL1 (Homo sapiens) | 6480464 | CTD | MCL1 protein results in decreased susceptibility to Doxorubicin | PMID:20856197 | Mcl1 | increases expression | ISO | MCL1 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of MCL1 mRNA | PMID:29803840 | Mcl1 | multiple interactions | ISO | MCL1 (Homo sapiens) | 6480464 | CTD | [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in decreased expression of MCL1 protein; [PI103 co-treated with Doxorubicin] results in decreased expression of MCL1 protein; MCL1 protein results in decreased susceptibility to [Doxorubicin co-treated with PI103]; wortmannin promotes the reaction [Doxorubicin results in decreased expression of MCL1 protein] | PMID:17935137 PMID:20856197 | | ||||||||||||||||||||||
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