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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb4decreases expressionISOERBB4 (Homo sapiens)6480464CTDEstradiol results in decreased expression of ERBB4 mRNAPMID:17872378 PMID:19619570 PMID:21185374
Erbb4multiple interactionsISOERBB4 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ERBB4 mRNA; ERBB4 protein promotes the reaction [Estradiol results in increased expression of PGR mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of ERBB4 mRNA]PMID:19619570 PMID:20550710 PMID:21185374
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