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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620474
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sox9
Name: SRY-box transcription factor 9
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox9increases expressionISOSox9 (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of SOX9 mRNA; Carbon Tetrachloride results in increased expression of SOX9 proteinPMID:31919559 PMID:32579217 PMID:32996673
Sox9increases response to substanceISOSox9 (Mus musculus)6480464CTDSOX9 results in increased susceptibility to Carbon TetrachloridePMID:32579217
Sox9multiple interactionsISOSox9 (Mus musculus)6480464CTD[Carbon Tetrachloride results in increased expression of SOX9 protein] promotes the reaction [SOX9 protein binds to H19 promoter]; [Ethanol co-treated with Carbon Tetrachloride] results in decreased methylation of SOX9 promoter; [Ethanol co-treated with Carbon Tetrachloride] results in increased expression of SOX9 mRNA; Carbon Tetrachloride promotes the reaction [Ethanol results in decreased expression of SOX9 protein]; GANT 61 inhibits the reaction [Carbon Tetrachloride results in increased expression of SOX9 mRNA]; SOX9 promotes the reaction [Carbon Tetrachloride results in increased expression of H19 mRNA]PMID:28285099 PMID:32579217 PMID:32996673
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