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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620446
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Shc1
Name: SHC adaptor protein 1
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Shc1affects response to substanceISOSHC1 (Homo sapiens)6480464CTDSHC1 protein affects the susceptibility to diallyl trisulfidePMID:21616139
Shc1decreases response to substanceISOSHC1 (Homo sapiens)6480464CTDSHC1 protein modified form results in decreased susceptibility to diallyl trisulfidePMID:22020565
Shc1increases phosphorylationISOSHC1 (Homo sapiens)6480464CTDdiallyl trisulfide results in increased phosphorylation of SHC1 proteinPMID:21616139 PMID:22020565
Shc1multiple interactionsISOSHC1 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [diallyl trisulfide results in increased phosphorylation of SHC1 protein]; SHC1 protein affects the reaction [diallyl trisulfide results in decreased expression of FTMT protein]; SHC1 protein modified form inhibits the reaction [diallyl trisulfide results in decreased phosphorylation of AKT1 protein]PMID:21616139 PMID:22020565
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