GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Shc1 | affects localization | EXP | | 6480464 | CTD | Doxorubicin affects the localization of SHC1 protein modified form | PMID:26318906 | Shc1 | increases oxidation | EXP | | 6480464 | CTD | Doxorubicin results in increased oxidation of SHC1 protein | PMID:26678157 | Shc1 | increases response to substance | EXP | | 6480464 | CTD | SHC1 protein results in increased susceptibility to Doxorubicin | PMID:26318906 | Shc1 | multiple interactions | EXP | | 6480464 | CTD | Doxorubicin promotes the reaction [SHC1 protein binds to FOXO3A protein]; Doxorubicin results in increased expression of and results in decreased phosphorylation of and affects the localization of SHC1 protein; hispidin inhibits the reaction [Doxorubicin results in increased expression of and results in decreased phosphorylation of and affects the localization of SHC1 protein]; SHC1 protein promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]; SHC1 protein promotes the reaction [Doxorubicin results in increased expression of TP53 protein] | PMID:26318906 | Shc1 | decreases expression | ISO | SHC1 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of SHC1 mRNA | PMID:29803840 | | ||||||||||||||||||||||
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