GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Shc1 | decreases response to substance | ISO | SHC1 (Homo sapiens) | 6480464 | CTD | SHC1 results in decreased susceptibility to Cisplatin | PMID:21849418 | Shc1 | increases expression | ISO | Shc1 (Mus musculus) | 6480464 | CTD | Cisplatin results in increased expression of SHC1 mRNA; Cisplatin results in increased expression of SHC1 protein | PMID:26768586 | Shc1 | increases phosphorylation | ISO | Shc1 (Mus musculus) | 6480464 | CTD | Cisplatin results in increased phosphorylation of SHC1 protein | PMID:20547441 | Shc1 | increases response to substance | ISO | SHC1 (Homo sapiens) | 6480464 | CTD | SHC1 protein results in increased susceptibility to Cisplatin | PMID:20547441 | Shc1 | multiple interactions | ISO | Shc1 (Mus musculus) | 6480464 | CTD | Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]; ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 protein]; MAP2K1 protein promotes the reaction [Cisplatin results in increased phosphorylation of SHC1 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]]; U 0126 inhibits the reaction [Cisplatin results in increased phosphorylation of SHC1 protein] | PMID:20547441 PMID:26768586 | |
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