GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Shc1 | multiple interactions | EXP | | 6480464 | CTD | [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 mRNA; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of SHC1 protein | PMID:22465879 | Shc1 | increases phosphorylation | ISO | SHC1 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased phosphorylation of SHC1 protein | PMID:23094148 | Shc1 | multiple interactions | ISO | SHC1 (Homo sapiens) | 6480464 | CTD | Estradiol binds to and results in increased phosphorylation of SHC1 protein; Estradiol promotes the reaction [ESR1 protein binds to SHC1 protein]; Estradiol promotes the reaction [SHC1 protein binds to ESR1 protein]; Estradiol promotes the reaction [SHC1 protein binds to IGF1R protein]; IGF1R mutant form inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SHC1 protein]] | PMID:16024245 PMID:23094148 | | ||||||||||||||||||||||
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