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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620441
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl4
Name: C-C motif chemokine ligand 4
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl4increases expressionISOCcl4 (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased expression of CCL4 proteinPMID:31351099
Ccl4multiple interactionsISOCCL4 (Homo sapiens)6480464CTD[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CCL4 mRNA; [Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL4 protein; [Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CCL4 mRNA; [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL4 protein; sodium bichromate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of CCL4 protein]PMID:17572062 PMID:17685462 PMID:18958680 PMID:9122163
Ccl4multiple interactionsISOCcl4 (Mus musculus)6480464CTDdecursin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL4 protein]PMID:31351099
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