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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620441
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl4
Name: C-C motif chemokine ligand 4
Acc ID: CHEBI:32234
Term: titanium dioxide
Definition: A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.
Chemical ID: MESH:C009495
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl4increases expressionEXP 6480464CTDtitanium dioxide results in increased expression of CCL4 mRNAPMID:29774637
Ccl4increases expressionISOCCL4 (Homo sapiens)6480464CTDtitanium dioxide results in increased expression of CCL4 mRNAPMID:19695317
Ccl4increases expressionISOCcl4 (Mus musculus)6480464CTDtitanium dioxide results in increased expression of CCL4 mRNA; titanium dioxide results in increased expression of CCL4 proteinPMID:19464567 PMID:23557971 PMID:27760801
Ccl4increases secretionISOCCL4 (Homo sapiens)6480464CTDtitanium dioxide results in increased secretion of CCL4 proteinPMID:20005940
Ccl4multiple interactionsISOCcl4 (Mus musculus)6480464CTD[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CCL4 mRNAPMID:29950665
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