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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620441
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl4
Name: C-C motif chemokine ligand 4
Acc ID: CHEBI:3020
Term: benzalkonium chloride
Definition: A class of quaternary ammonium chloride salts in which the nitrogen is substituted by a benzyl group, two methyl groups and an even-numbered alkyl chain.
Chemical ID: MESH:D001548
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl4decreases expressionISOCCL4 (Homo sapiens)6480464CTDBenzalkonium Compounds results in decreased expression of CCL4 mRNA; Benzalkonium Compounds results in decreased expression of CCL4 proteinPMID:18353026 PMID:20713136
Ccl4increases expressionISOCcl4 (Mus musculus)6480464CTDBenzalkonium Compounds results in increased expression of CCL4 proteinPMID:30517752
Ccl4multiple interactionsISOCcl4 (Mus musculus)6480464CTD[IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in increased expression of CCL4 proteinPMID:31158415
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