GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl4 | decreases expression | ISO | CCL4 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in decreased expression of CCL4 mRNA | PMID:22777745 | Ccl4 | increases expression | ISO | CCL4 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased expression of CCL4 mRNA; Lipopolysaccharides results in increased expression of CCL4 protein | PMID:14966191 PMID:15788441 PMID:17529908 PMID:19020770 PMID:21352583 PMID:24707119 PMID:26111115 PMID:27568862 PMID:27783115 PMID:35811015 | Ccl4 | increases expression | ISO | Ccl4 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of CCL4 mRNA | PMID:10027076 PMID:10975854 PMID:12057914 PMID:23107598 PMID:25890327 PMID:26582142 | Ccl4 | increases secretion | ISO | CCL4 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased secretion of CCL4 protein | PMID:15289356 PMID:18390722 PMID:19211157 PMID:21913898 PMID:32800949 | Ccl4 | multiple interactions | ISO | CCL4 (Homo sapiens) | 6480464 | CTD | 2'-hydroxyflavanone inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL4 mRNA]; 6-formylindolo(3,2-b)carbazole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL4 mRNA; [Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CCL4 mRNA; [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CCL4 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of CCL4 mRNA; [usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL4 mRNA; coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 protein]; Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Particulate Matter inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]; roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]; Vehicle Emissions inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA] | PMID:14966191 PMID:19211157 PMID:21913898 PMID:22777745 PMID:27568862 PMID:27783115 PMID:30768972 PMID:32800949 PMID:35811015 PMID:9122163 | Ccl4 | multiple interactions | ISO | Ccl4 (Mus musculus) | 6480464 | CTD | (+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL4 protein]; Indirubin E804 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL4 mRNA]; Lipopolysaccharides inhibits the reaction [Indirubin E804 results in increased expression of CCL4 mRNA]; Lipopolysaccharides results in increased expression of and results in increased secretion of CCL4 protein | PMID:23107598 PMID:25890327 PMID:26918785 | | ||||||||||||||||||||||
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