GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | 1,2-Dimethylhydrazine results in increased expression of NFE2L2 protein | PMID:30720227 PMID:32028820 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | [1,2-Dimethylhydrazine co-treated with morin] affects the localization of NFE2L2 protein; zingerone inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NFE2L2 protein] | PMID:30720227 PMID:32028820 | Nfe2l2 | affects response to substance | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | [NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which affects the susceptibility to sulforaphane; NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine | PMID:26388957 | Nfe2l2 | decreases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | 1,2-Dimethylhydrazine results in decreased expression of NFE2L2 mRNA | PMID:22206623 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NFE2L2 mRNA; [NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of CDKN2B mRNA; [NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of MLH1 mRNA; [NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of SERPINB5 mRNA; [NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of CDKN2A mRNA; [NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of ETS1 mRNA; [NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of IGF2R mRNA; [NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of TRP53 mRNA; NFE2L2 protein affects the reaction [1,2-Dimethylhydrazine affects the expression of HDAC3 protein]; NFE2L2 protein affects the reaction [sulforaphane affects the reaction [1,2-Dimethylhydrazine affects the expression of HDAC3 protein]]; sulforaphane inhibits the reaction [[NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of CDKN2A mRNA] | PMID:22206623 PMID:26388957 | |
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