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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:4038
Term: Cynaropicrin
Definition: A sesquiterpene lactone that has formula C19H22O6.
Chemical ID: MESH:C075687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDcynaropicrin affects the localization of NFE2L2 proteinPMID:25680693
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDcynaropicrin results in increased expression of NFE2L2 mRNAPMID:25680693
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDAHR mutant form inhibits the reaction [cynaropicrin affects the localization of NFE2L2 protein]; AHR mutant form inhibits the reaction [cynaropicrin results in increased expression of NFE2L2 mRNA]; NFE2L2 mutant form inhibits the reaction [cynaropicrin results in increased expression of NQO1 mRNA]PMID:25680693
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