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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2increases acetylationEXP 6480464CTDchromium hexavalent ion results in increased acetylation of NFE2L2 proteinPMID:35024197
Nfe2l2multiple interactionsEXP 6480464CTD[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of NFE2L2 mRNA; [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in decreased expression of NFE2L2 protein; Resveratrol inhibits the reaction [chromium hexavalent ion results in increased acetylation of NFE2L2 protein]PMID:35024197 PMID:36849043
Nfe2l2increases activityISONFE2L2 (Homo sapiens)6480464CTDchromium hexavalent ion results in increased activity of NFE2L2 proteinPMID:30715550
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDchromium hexavalent ion promotes the reaction [NFE2L2 protein binds to SIRT3 promoter]PMID:30715550
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of NFE2L2 mRNA; [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of NFE2L2 proteinPMID:25820237
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