GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | decreases expression | EXP | | 6480464 | CTD | Mercuric Chloride results in decreased expression of NFE2L2 protein | PMID:32134168 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | [lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of NFE2L2 protein; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein; [Sodium Selenite co-treated with zinc chloride] inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of NFE2L2 protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of NFE2L2 protein]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein] | PMID:27837179 PMID:32134168 PMID:36646412 | Nfe2l2 | affects localization | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Mercuric Chloride affects the localization of NFE2L2 protein | PMID:24816296 | Nfe2l2 | affects response to substance | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | [NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Mercuric Chloride | PMID:19303893 | Nfe2l2 | decreases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Mercuric Chloride results in decreased expression of NFE2L2 mRNA | PMID:23202902 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Mercuric Chloride results in increased expression of NFE2L2 protein | PMID:17959236 PMID:21843634 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | [Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of NFE2L2 protein; Acetylcysteine inhibits the reaction [Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of NFE2L2 protein]; Mercuric Chloride affects the localization of and results in increased stability of NFE2L2 protein; Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]; NFE2L2 mRNA affects the reaction [Mercuric Chloride results in increased activity of NQO1 protein]; NFE2L2 mRNA affects the reaction [Mercuric Chloride results in increased expression of NQO1 mRNA]; sodium selenide inhibits the reaction [Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; sodium selenide inhibits the reaction [Mercuric Chloride results in increased expression of NFE2L2 protein]; Sodium Selenite affects the reaction [Mercuric Chloride affects the localization of NFE2L2 protein] | PMID:17959236 PMID:21843634 PMID:24816296 PMID:30359721 | |
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