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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionEXP 6480464CTDMercuric Chloride results in decreased expression of NFE2L2 proteinPMID:32134168
Nfe2l2multiple interactionsEXP 6480464CTD[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of NFE2L2 protein; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA; [Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein; [Sodium Selenite co-treated with zinc chloride] inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of NFE2L2 protein]; alpha-Tocopherol inhibits the reaction [Mercuric Chloride results in decreased expression of NFE2L2 protein]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of NFE2L2 protein]PMID:27837179 PMID:32134168 PMID:36646412
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDMercuric Chloride affects the localization of NFE2L2 proteinPMID:24816296
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTD[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Mercuric ChloridePMID:19303893
Nfe2l2decreases expressionISONfe2l2 (Mus musculus)6480464CTDMercuric Chloride results in decreased expression of NFE2L2 mRNAPMID:23202902
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDMercuric Chloride results in increased expression of NFE2L2 proteinPMID:17959236 PMID:21843634
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[Mercuric Chloride results in increased abundance of Mercury] which results in decreased expression of NFE2L2 protein; Acetylcysteine inhibits the reaction [Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of NFE2L2 protein]; Mercuric Chloride affects the localization of and results in increased stability of NFE2L2 protein; Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]; NFE2L2 mRNA affects the reaction [Mercuric Chloride results in increased activity of NQO1 protein]; NFE2L2 mRNA affects the reaction [Mercuric Chloride results in increased expression of NQO1 mRNA]; sodium selenide inhibits the reaction [Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; sodium selenide inhibits the reaction [Mercuric Chloride results in increased expression of NFE2L2 protein]; Sodium Selenite affects the reaction [Mercuric Chloride affects the localization of NFE2L2 protein]PMID:17959236 PMID:21843634 PMID:24816296 PMID:30359721
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