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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionEXP 6480464CTDBleomycin results in decreased expression of NFE2L2 mRNA; Bleomycin results in decreased expression of NFE2L2 proteinPMID:26093215 PMID:26768587
Nfe2l2increases expressionEXP 6480464CTDBleomycin results in increased expression of NFE2L2 proteinPMID:23523906
Nfe2l2multiple interactionsEXP 6480464CTDBerberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]; celastrol inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]; Methylprednisolone inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 mRNA]PMID:23523906 PMID:26093215 PMID:26768587
Nfe2l2affects localizationISONfe2l2 (Mus musculus)6480464CTDBleomycin affects the localization of NFE2L2 proteinPMID:23570914
Nfe2l2decreases expressionISONfe2l2 (Mus musculus)6480464CTDBleomycin results in decreased expression of NFE2L2 proteinPMID:23570914
Nfe2l2increases phosphorylationISONfe2l2 (Mus musculus)6480464CTDBleomycin results in increased phosphorylation of NFE2L2 proteinPMID:23570914
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDcaffeic acid phenethyl ester inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 protein]; U 0126 inhibits the reaction [Bleomycin affects the localization of NFE2L2 protein]; U 0126 inhibits the reaction [Bleomycin results in increased phosphorylation of NFE2L2 protein]PMID:23570914
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