GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | affects localization | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | arsenite affects the localization of NFE2L2 protein | PMID:19429247 | Nfe2l2 | affects response to substance | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | NFE2L2 protein affects the susceptibility to arsenite | PMID:22476201 | Nfe2l2 | decreases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | arsenite results in decreased expression of NFE2L2 mRNA; arsenite results in decreased expression of NFE2L2 protein | PMID:28688901 | Nfe2l2 | increases activity | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | arsenite results in increased activity of NFE2L2 protein | PMID:25701757 PMID:33412187 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | arsenite results in increased expression of NFE2L2 mRNA; arsenite results in increased expression of NFE2L2 protein | PMID:22476201 PMID:29572906 PMID:33451022 | Nfe2l2 | increases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | arsenite results in increased expression of NFE2L2 mRNA; arsenite results in increased expression of NFE2L2 protein | PMID:32980394 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased susceptibility to arsenite; [lipopolysaccharide, E coli O55-B5 co-treated with arsenite] results in increased expression of NFE2L2 protein; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of NFE2L2 mRNA; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of NFE2L2 protein; arsenite inhibits the reaction [epigallocatechin gallate results in increased expression of NFE2L2 mRNA]; arsenite promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; arsenite results in increased expression of and results in increased activity of NFE2L2 protein; arsenite results in increased localization of and results in increased activity of NFE2L2 protein; epigallocatechin gallate inhibits the reaction [arsenite results in increased expression of NFE2L2 mRNA]; KEAP1 protein affects the reaction [arsenite results in increased expression of NFE2L2 mRNA]; KEAP1 protein affects the reaction [arsenite results in increased expression of NFE2L2 protein]; MIR155 promotes the reaction [arsenite results in decreased expression of NFE2L2 mRNA]; MIR155 promotes the reaction [arsenite results in decreased expression of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with arsenite] results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]; NFE2L2 mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B mRNA]]; NFE2L2 mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]]; NFE2L2 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of SQSTM1 mRNA]; NFE2L2 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [arsenite affects the expression of NFE2L1 mRNA]; NFE2L2 protein affects the reaction [arsenite affects the expression of NFE2L1 protein]; NFE2L2 protein affects the reaction [arsenite affects the expression of NQO1 protein]; NFE2L2 protein affects the reaction [arsenite results in decreased expression of PLAT mRNA]; NFE2L2 protein affects the reaction [arsenite results in decreased secretion of PLAT protein]; NFE2L2 protein affects the reaction [arsenite results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [arsenite results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [arsenite results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [arsenite results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [arsenite results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [arsenite results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [arsenite results in increased expression of SRXN1 mRNA]; NFE2L2 protein alternative form affects the reaction [arsenite results in decreased expression of CDH1 protein]; NFE2L2 protein alternative form affects the reaction [arsenite results in increased expression of SNAI1 mRNA]; NFE2L2 protein alternative form affects the reaction [arsenite results in increased expression of TWIST2 mRNA]; NFE2L2 protein inhibits the reaction [arsenite results in increased expression of KEAP1 mRNA]; NFE2L2 protein inhibits the reaction [arsenite results in increased expression of KEAP1 protein]; NFE2L2 protein inhibits the reaction [arsenite results in increased expression of LINC-ROR mRNA]; NFE2L2 protein promotes the reaction [arsenite results in decreased expression of KEAP1 mRNA]; NFE2L2 protein promotes the reaction [arsenite results in decreased expression of KEAP1 protein]; SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of NFE2L2 protein] | PMID:18550526 PMID:22476201 PMID:25680285 PMID:28688901 PMID:29572906 PMID:31781319 PMID:32030632 PMID:33451022 PMID:35124418 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | [Dexamethasone co-treated with arsenite] results in increased activity of NFE2L2 protein; NFE2L1 alternative form affects the reaction [arsenite results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with arsenite] results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]; NFE2L2 gene mutant form inhibits the reaction [arsenite inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B mRNA]]; NFE2L2 gene mutant form inhibits the reaction [arsenite results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [arsenite results in increased expression of HMOX1 mRNA]; Rifampin inhibits the reaction [arsenite results in increased activity of NFE2L2 protein]; Sodium Selenite promotes the reaction [arsenite affects the localization of NFE2L2 protein] | PMID:10473555 PMID:19429247 PMID:25680285 PMID:30203046 PMID:32980394 PMID:33412187 | | ||||||||||||||||||||||
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