Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of NFE2L2; sodium arsenite results in decreased expression of NFE2L2 mRNA; sodium arsenite results in decreased expression of NFE2L2 proteinPMID:20699118 PMID:24062023 PMID:24952339 PMID:26085057 PMID:26767369 PMID:27174133 PMID:27425645 PMID:27966075
Nfe2l2increases expressionEXP 6480464CTDsodium arsenite results in increased expression of NFE2L2 mRNA; sodium arsenite results in increased expression of NFE2L2 proteinPMID:19933942 PMID:20699118 PMID:21465251
Nfe2l2multiple interactionsEXP 6480464CTD[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of NFE2L2 protein; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NFE2L2 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein; [Sodium Selenite co-treated with Plant Extracts] inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; [Sodium Selenite co-treated with zinc chloride] inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of NFE2L2 protein]; coenzyme Q10 inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 protein]; Melatonin promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein]; naringin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; Plant Extracts inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; Silybin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2]; Sodium Selenite inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; sulforaphane inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NFE2L2 protein]PMID:24062023 PMID:24952339 PMID:26085057 PMID:27174133 PMID:30835071 PMID:35598369 PMID:36646412
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDsodium arsenite affects the localization of NFE2L2 proteinPMID:16959797 PMID:26291278
Nfe2l2affects localizationISONfe2l2 (Mus musculus)6480464CTDsodium arsenite affects the localization of NFE2L2 proteinPMID:27723467 PMID:28237703
Nfe2l2affects response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 gene SNP affects the susceptibility to sodium arsenitePMID:26039680
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTD[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to sodium arsenite; NFE2L2 protein affects the susceptibility to sodium arsenitePMID:19303893 PMID:30742845
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of NFE2L2 proteinPMID:27459794
Nfe2l2decreases expressionISONfe2l2 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of NFE2L2 mRNAPMID:19822182 PMID:33242462
Nfe2l2decreases response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 gene mutant form results in decreased susceptibility to sodium arsenite; NFE2L2 protein results in decreased susceptibility to sodium arsenitePMID:17765279 PMID:32682831
Nfe2l2decreases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein results in decreased susceptibility to sodium arsenitePMID:20932822
Nfe2l2increases activityISONFE2L2 (Homo sapiens)6480464CTDsodium arsenite results in increased activity of NFE2L2 promoter; sodium arsenite results in increased activity of NFE2L2 proteinPMID:12220541 PMID:20805060 PMID:21643505 PMID:27286880
Nfe2l2increases activityISONfe2l2 (Mus musculus)6480464CTDsodium arsenite results in increased activity of NFE2L2 proteinPMID:30114225
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of NFE2L2 mRNA; sodium arsenite results in increased expression of NFE2L2 proteinPMID:18417180 PMID:20519851 PMID:20805060 PMID:21809430 PMID:22367689 PMID:23165982 PMID:23376440 PMID:23738048 PMID:24516582 PMID:25201354 PMID:26404762 PMID:26409248 PMID:27286880 PMID:27774770 PMID:28125038 PMID:29081891 PMID:30186748 PMID:30309986 PMID:32066060 PMID:32682831 PMID:33814512 PMID:34758851
Nfe2l2increases expressionISONfe2l2 (Mus musculus)6480464CTDsodium arsenite results in increased expression of NFE2L2 mRNA; sodium arsenite results in increased expression of NFE2L2 proteinPMID:12745069 PMID:17003472 PMID:21396911 PMID:26371860 PMID:26473898 PMID:26483381 PMID:27165637 PMID:27723467 PMID:28549828 PMID:28843991 PMID:29108910 PMID:30130555 PMID:32194376 PMID:32760496 PMID:34272803 PMID:35679981 PMID:36435854
Nfe2l2increases localizationISONFE2L2 (Homo sapiens)6480464CTDsodium arsenite results in increased localization of NFE2L2 proteinPMID:16775837
Nfe2l2increases response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 protein results in increased susceptibility to sodium arsenitePMID:27286880
Nfe2l2increases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 gene mutant form results in increased susceptibility to sodium arsenitePMID:29108910
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite affects the localization of NFE2L2 protein]; [NFE2L1 protein alternative form co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of NFE2L2 mRNA; [sodium arsenite co-treated with daphnetin] results in increased expression of NFE2L2 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFE2L2 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of NFE2L2 mRNA; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of NFE2L2 protein; Acetylcysteine inhibits the reaction [sodium arsenite affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HSF1 promoter]]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to NQO1 promoter]]; Brefeldin A inhibits the reaction [sodium arsenite results in increased activity of NFE2L2 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; Cycloheximide inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; Decitabine inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; diacetyldichlorofluorescein inhibits the reaction [sodium arsenite affects the localization of NFE2L2 protein]; HMOX1 protein promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; KEAP1 protein promotes the reaction [sodium arsenite results in increased expression of and results in increased activity of NFE2L2 protein]; KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; NFE2L1 protein alternative form promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form inhibits the reaction [sodium arsenite affects the localization of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [sodium arsenite results in increased expression of FTH1 mRNA]; NFE2L2 mutant form inhibits the reaction [sodium arsenite results in increased expression of FTL mRNA]; NFE2L2 mutant form inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [sodium arsenite results in increased expression of NQO1 protein]; NFE2L2 promotes the reaction [sodium arsenite promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; NFE2L2 promotes the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; NFE2L2 promotes the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [[Curcumin co-treated with sodium arsenite] promotes the reaction TFEB protein]; NFE2L2 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of SQSTM1 mRNA]; NFE2L2 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of BCL2 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in decreased expression of SOD2 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of LAMP1 protein]]; NFE2L2 protein affects the reaction [Curcumin promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]]; NFE2L2 protein affects the reaction [sodium arsenite results in decreased cleavage of CASP3 protein]; NFE2L2 protein affects the reaction [sodium arsenite results in decreased expression of BAX protein]; NFE2L2 protein affects the reaction [sodium arsenite results in decreased expression of DDIT3 protein]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of BCL2 protein]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CCNE1 protein]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CDK2 protein]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of HSF1 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of HSF1 protein]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of HSPA1A mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of MCL1 protein]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of NQO1 protein]; NFE2L2 protein inhibits the reaction [sodium arsenite inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; NFE2L2 protein inhibits the reaction [sodium arsenite results in increased expression of UBC mRNA]; NFE2L2 protein promotes the reaction [sodium arsenite inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of F3 mRNA]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of F3 protein]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of HIF1A protein]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of KRT16 mRNA]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of SQSTM1 mRNA]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; NOX4 protein promotes the reaction [sodium arsenite results in increased activity of NFE2L2 protein]; Potassium Dichromate inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; Potassium Dichromate inhibits the reaction [sodium arsenite results in increased localization of NFE2L2 protein]; sodium arsenite affects the localization of and results in increased activity of NFE2L2 protein; sodium arsenite inhibits the reaction [KEAP1 protein mutant form results in increased ubiquitination of NFE2L2 protein]; sodium arsenite inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; sodium arsenite promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; sodium arsenite promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]; sodium arsenite promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; sodium arsenite promotes the reaction [NFE2L2 protein binds to HSF1 promoter]; sodium arsenite promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; sodium arsenite results in decreased ubiquitination of and results in decreased degradation of NFE2L2 protein; sodium arsenite results in increased expression of and affects the localization of NFE2L2 protein; sodium arsenite results in increased expression of and results in decreased degradation of and results in increased localization of NFE2L2 protein; sodium arsenite results in increased expression of and results in increased activity of NFE2L2 protein; SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of NFE2L2 protein]; SQSTM1 protein promotes the reaction [sodium arsenite results in increased expression of and results in increased activity of NFE2L2 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; Thapsigargin inhibits the reaction [sodium arsenite results in increased activity of NFE2L2 protein]; Tretinoin inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; tubastatin A inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; Tunicamycin inhibits the reaction [sodium arsenite results in increased activity of NFE2L2 protein]; U 0126 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]PMID:10874044 PMID:16775837 PMID:16959797 PMID:18417180 PMID:18629308 PMID:20083128 PMID:20100676 PMID:20519851 PMID:20805060 PMID:22367689 PMID:23589329 PMID:23699174 PMID:23738048 PMID:24161444 PMID:25201354 PMID:26291278 PMID:26404762 PMID:26409248 PMID:26535918 PMID:27286880 PMID:27774770 PMID:28125038 PMID:28229933 PMID:30186748 PMID:30309986 PMID:30738023 PMID:31781319 PMID:32188015 PMID:33261869 PMID:33434570 PMID:33814512 PMID:34758851
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD[[sodium arsenite results in increased abundance of Arsenic] which co-treated with biochanin A] results in increased expression of NFE2L2 mRNA; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with epigallocatechin gallate] results in increased expression of NFE2L2 mRNA; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Phloretin] results in increased expression of NFE2L2 mRNA; [NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]; [NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]; [NFE2L2 protein affects the susceptibility to sodium arsenite] which affects the expression of ACP5 protein; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NFE2L2 protein; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; Acetylcysteine affects the reaction [NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]]; Chlorogenic Acid inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; Curcumin promotes the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; DOT1L protein affects the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; NFE2L1 protein alternative form inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; NFE2L1 protein alternative form inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]; NFE2L2 protein affects the reaction [sodium arsenite results in decreased expression of FABP4 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in decreased expression of S100A9 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in decreased expression of SLC10A2 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in decreased expression of UGT2B37 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of ABCC3 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of ACOT3 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of ACSL1 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of BTG2 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CAR3 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CES1D mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CES1F mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CES1G mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CYP1A2 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CYP2A5 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CYP2C37 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CYP2D9 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CYP3A11 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of CYP4A10 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of HNF4A mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of KHK mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of SORD mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of SRXN1 mRNA]; NFE2L2 protein affects the reaction [sodium arsenite results in increased expression of TKFC mRNA]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to sodium arsenite]; Plant Extracts inhibits the reaction [sodium arsenite affects the localization of NFE2L2 protein]; Plant Extracts inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; SB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; SB 203580 affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; SB 203580 affects the reaction [NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]]; sodium arsenite inhibits the reaction [[CUL3 protein binds to KEAP1 protein] which binds to and results in increased ubiquitination of NFE2L2 protein]; sodium arsenite promotes the reaction [[NFE2L2 protein binds to MAFG protein] which binds to NQO1 promoter]; sodium arsenite promotes the reaction [[NFE2L2 protein binds to MAFK protein] which binds to NQO1 promoter]; sodium arsenite results in decreased ubiquitination of and results in decreased degradation of and results in increased stability of and results in increased expression of NFE2L2 proteinPMID:16785233 PMID:18404528 PMID:20932822 PMID:21266531 PMID:22003191 PMID:26291278 PMID:27723467 PMID:28549828 PMID:29108910 PMID:30130555 PMID:30742845 PMID:31238026 PMID:33242462 PMID:33410021 PMID:33933676 PMID:34272803
Go Back to source page   Continue to Ontology report