GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | affects localization | EXP | | 6480464 | CTD | Acetylcysteine affects the localization of NFE2L2 protein | PMID:30633982 | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | Acetylcysteine results in increased expression of NFE2L2 mRNA | PMID:30633982 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride results in increased activity of NFE2L2 protein]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride results in increased expression of NFE2L2 protein]; [Particulate Matter co-treated with Acetylcysteine] results in increased expression of NFE2L2 protein; Acetylcysteine affects the reaction [yttrium chloride affects the expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of and affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [aureusidin affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [decamethrin affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [decamethrin results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [decamethrin results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in decreased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [triptolide affects the expression of NFE2L2 protein]; Acetylcysteine promotes the reaction [Acrylamide results in increased expression of and affects the localization of NFE2L2 protein]; Acetylcysteine promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; Sodium Fluoride promotes the reaction [Acetylcysteine affects the localization of NFE2L2 protein] | PMID:17540521 PMID:21384399 PMID:22129741 PMID:24634002 PMID:25169008 PMID:26079211 PMID:28583816 PMID:29426002 PMID:30104959 PMID:30633982 PMID:31790703 PMID:33797725 PMID:34358621 PMID:35088107 PMID:35285579 PMID:36813253 | Nfe2l2 | affects localization | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Acetylcysteine affects the localization of NFE2L2 protein | PMID:22564156 | Nfe2l2 | decreases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Acetylcysteine results in decreased expression of NFE2L2 mRNA | PMID:36786954 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Acetylcysteine results in increased expression of NFE2L2 mRNA; Acetylcysteine results in increased expression of NFE2L2 protein | PMID:35123993 PMID:35430258 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Acetylcysteine affects the reaction [Chlorpyrifos affects the expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [4-(methylthio)-3-butenyl isothiocyanate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Ammonium Chloride results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Capsaicin results in increased localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [dimethoxyethyl phthalate results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Docosahexaenoic Acids affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Docosahexaenoic Acids promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]]; Acetylcysteine inhibits the reaction [Docosahexaenoic Acids results in increased expression of and affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased activity of NFE2L2 promoter]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]]; Acetylcysteine inhibits the reaction [Indomethacin results in increased localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [NFE2L2 protein affects the reaction [Silver results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine inhibits the reaction [NFE2L2 protein affects the susceptibility to Silver]; Acetylcysteine inhibits the reaction [nickel chloride results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Silver analog results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HSF1 promoter]]; Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to NQO1 promoter]]; Acetylcysteine inhibits the reaction [sulforaphane affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [sulforaphane results in increased phosphorylation of and results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of NFE2L2 protein] | PMID:11909699 PMID:16631525 PMID:16806455 PMID:16959797 PMID:17959236 PMID:17979524 PMID:18156441 PMID:19033392 PMID:19234301 PMID:19350554 PMID:20851755 PMID:21643505 PMID:21728338 PMID:21787718 PMID:22019695 PMID:22546375 PMID:24126012 PMID:24355171 PMID:24361488 PMID:24489685 PMID:25003661 PMID:25263748 PMID:25341683 PMID:25568320 PMID:26163453 PMID:26291278 PMID:27867098 PMID:27917510 PMID:28807874 PMID:29155359 PMID:29792947 PMID:29966676 PMID:30309986 PMID:30965051 PMID:33930485 PMID:34214916 PMID:35123993 PMID:35430258 PMID:37257343 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | [6-formylindolo(3,2-b)carbazole co-treated with Acetylcysteine] results in decreased expression of NFE2L2 mRNA; [Acetylcysteine co-treated with Particulate Matter] results in decreased expression of NFE2L2 mRNA; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of CTSK mRNA]]; Acetylcysteine affects the reaction [NFE2L2 protein affects the reaction [sodium arsenite affects the expression of NFATC1 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NFE2L2 protein]]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Particulate Matter analog affects the localization of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions analog affects the localization of NFE2L2 protein] | PMID:15322212 PMID:17980396 PMID:24157283 PMID:29061315 PMID:30742845 PMID:34036678 PMID:36786954 PMID:37353053 PMID:37369159 PMID:37598416 PMID:37692514 | | ||||||||||||||||||||||
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