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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects localizationEXP 6480464CTDresveratrol affects the localization of NFE2L2 proteinPMID:20486211 PMID:22627169
Nfe2l2decreases expressionEXP 6480464CTDresveratrol results in decreased expression of NFE2L2 proteinPMID:22610192
Nfe2l2increases expressionEXP 6480464CTDresveratrol results in increased expression of NFE2L2 mRNA; resveratrol results in increased expression of NFE2L2 proteinPMID:18616940 PMID:20501860 PMID:21850487 PMID:24395567 PMID:24894866
Nfe2l2multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol affects the localization of NFE2L2 protein]; [Dimethyl Sulfoxide co-treated with Resveratrol] inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]; [Resveratrol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NFE2L2; Resveratrol affects the localization of and results in increased activity of NFE2L2 protein; Resveratrol analog inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 mRNA]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 mRNA]; Resveratrol inhibits the reaction [chromium hexavalent ion results in increased acetylation of NFE2L2 protein]; Resveratrol inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [Estradiol results in decreased expression of NFE2L2 mRNA]; Resveratrol inhibits the reaction [Estradiol results in decreased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [MIR136 promotes the reaction [Paraquat results in decreased expression of NFE2L2 protein]]; Resveratrol inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [Rotenone results in increased activity of NFE2L2 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; Resveratrol promotes the reaction [Diethylhexyl Phthalate results in increased expression of NFE2L2 mRNA]; Resveratrol promotes the reaction [Streptozocin affects the localization of NFE2L2 protein]; Resveratrol results in increased expression of and results in increased localization of NFE2L2 protein; sirtinol inhibits the reaction [Resveratrol results in increased expression of NFE2L2 protein]PMID:15882976 PMID:18616940 PMID:20486211 PMID:21439372 PMID:22610192 PMID:23551926 PMID:24327821 PMID:24395567 PMID:24740756 PMID:24894866 PMID:26361869 PMID:26497626 PMID:27016191 PMID:29935225 PMID:34067838 PMID:35024197 PMID:35236239
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDresveratrol affects the localization of NFE2L2 proteinPMID:22917016 PMID:23829535
Nfe2l2affects localizationISONfe2l2 (Mus musculus)6480464CTDResveratrol affects the localization of NFE2L2 proteinPMID:36584933
Nfe2l2affects response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 protein affects the susceptibility to resveratrolPMID:20418481
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein affects the susceptibility to ResveratrolPMID:20418481 PMID:30844440
Nfe2l2decreases activityISONfe2l2 (Mus musculus)6480464CTDResveratrol results in decreased activity of NFE2L2 proteinPMID:30114225 PMID:30203046
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDresveratrol results in decreased expression of NFE2L2 mRNAPMID:25667456
Nfe2l2decreases expressionISONfe2l2 (Mus musculus)6480464CTDResveratrol results in decreased expression of NFE2L2 mRNA; Resveratrol results in decreased expression of NFE2L2 proteinPMID:22610192
Nfe2l2decreases methylationISONFE2L2 (Homo sapiens)6480464CTDresveratrol results in decreased methylation of NFE2L2 promoterPMID:24894866
Nfe2l2increases activityISONFE2L2 (Homo sapiens)6480464CTDresveratrol results in increased activity of NFE2L2 promoter; resveratrol results in increased activity of NFE2L2 proteinPMID:20418481 PMID:21199573 PMID:23954466 PMID:25466015
Nfe2l2increases activityISONfe2l2 (Mus musculus)6480464CTDresveratrol results in increased activity of NFE2L2 proteinPMID:16322078 PMID:20486211 PMID:24036142
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDResveratrol results in increased expression of NFE2L2 mRNA; Resveratrol results in increased expression of NFE2L2 proteinPMID:20060927 PMID:26497626 PMID:26772155 PMID:26969377 PMID:28960787 PMID:37419272
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[Doxorubicin co-treated with Resveratrol] results in decreased expression of NFE2L2 protein; [IL1A protein co-treated with TNF protein co-treated with IFNG protein co-treated with Resveratrol] results in increased activity of NFE2L2 protein; [Lipopolysaccharides co-treated with Resveratrol] results in decreased expression of NFE2L2 mRNA; [Lipopolysaccharides co-treated with Resveratrol] results in increased expression of NFE2L2 protein; [Resveratrol co-treated with Arsenic Trioxide] results in increased expression of NFE2L2 protein; [Resveratrol co-treated with phenethyl isothiocyanate] results in increased expression of NFE2L2 mRNA; [Resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in decreased activity of NFE2L2 protein]; [Resveratrol co-treated with Polyphenols] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in decreased activity of NFE2L2 protein]; [Resveratrol results in increased activity of NFE2L2 protein] which results in decreased susceptibility to Paraquat; [Resveratrol results in increased activity of NFE2L2 protein] which results in decreased susceptibility to Pyruvaldehyde; [Resveratrol results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Resveratrol results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; [Resveratrol results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Resveratrol results in increased expression of and results in increased activity of NFE2L2 protein] which results in decreased susceptibility to Benzo(a)pyrene; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 protein; Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of NFE2L2 protein]; Ascorbic Acid inhibits the reaction [Resveratrol results in increased activity of NFE2L2 promoter]; NFE2L2 protein affects the reaction [Resveratrol affects the reaction [Pyruvaldehyde affects the expression of GLO1 protein]]; NFE2L2 protein affects the reaction [Resveratrol affects the reaction [Pyruvaldehyde affects the expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Resveratrol inhibits the reaction [Pyruvaldehyde affects the localization of SLC2A2 protein]]; NFE2L2 protein affects the reaction [Resveratrol inhibits the reaction [Pyruvaldehyde results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]; NFE2L2 protein affects the reaction [Resveratrol inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]]; NFE2L2 protein affects the reaction [Resveratrol results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [Resveratrol results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Resveratrol results in increased expression of NQO1 mRNA]; Paraquat promotes the reaction [Resveratrol results in increased expression of and results in increased activity of NFE2L2 protein]; PIK 75 inhibits the reaction [[Lipopolysaccharides co-treated with Resveratrol] results in increased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [deoxynivalenol results in decreased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [Estradiol results in decreased expression of NFE2L2 mRNA]; Resveratrol inhibits the reaction [Estradiol results in decreased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [Estradiol results in increased methylation of NFE2L2 promoter]; Resveratrol inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]; Resveratrol inhibits the reaction [Pyruvaldehyde results in decreased phosphorylation of NFE2L2 protein]; Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Resveratrol promotes the reaction [NFE2L2 protein binds to FTH1 enhancer]; Resveratrol results in increased expression of and results in increased activity of NFE2L2 protein; Resveratrol results in increased phosphorylation of and affects the localization of NFE2L2 proteinPMID:16948474 PMID:20418481 PMID:21199573 PMID:21289251 PMID:22192953 PMID:22493042 PMID:22917016 PMID:23829535 PMID:23954466 PMID:24894866 PMID:25130429 PMID:26497626 PMID:26667767 PMID:26772155 PMID:26969377 PMID:27818126 PMID:29876539 PMID:32070777 PMID:37419272
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD[Resveratrol co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased expression of NFE2L2 mRNA; [Resveratrol co-treated with HMGB1 protein] affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Resveratrol affects the reaction [Dextran Sulfate affects the expression of IL6 protein]]; NFE2L2 protein affects the reaction [Resveratrol affects the reaction [Dextran Sulfate affects the expression of TNF protein]]; NFE2L2 protein affects the reaction [Resveratrol inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]]; NFE2L2 protein affects the reaction [Resveratrol inhibits the reaction [Dietary Fats results in increased activity of CASP3 protein]]; NFE2L2 protein affects the reaction [Resveratrol inhibits the reaction [HMGB1 protein results in decreased expression of CDH5 protein]]; NFE2L2 protein affects the reaction [Resveratrol results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [Resveratrol results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [Resveratrol promotes the reaction [Azoxymethane results in increased expression of GSR mRNA]]; NFE2L2 protein promotes the reaction [Resveratrol promotes the reaction [Azoxymethane results in increased expression of HMOX1 mRNA]]; NFE2L2 protein promotes the reaction [Resveratrol results in increased expression of HMOX1 protein]; Resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased activity of NFE2L2 protein]; Resveratrol inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 mRNA]; Resveratrol inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA]; Resveratrol inhibits the reaction [HMGB1 protein results in decreased expression of NFE2L2 mRNA]; Resveratrol inhibits the reaction [HMGB1 protein results in decreased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of NFE2L2 protein]; Resveratrol promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; Resveratrol results in increased expression of and results in increased localization of NFE2L2 proteinPMID:16322078 PMID:20418481 PMID:21355597 PMID:24231106 PMID:24812660 PMID:25954969 PMID:25979658 PMID:27260466 PMID:30844440 PMID:34391968 PMID:36584933
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