GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | affects expression | EXP | | 6480464 | CTD | Carbon Tetrachloride affects the expression of NFE2L2 mRNA | PMID:32380060 | Nfe2l2 | affects localization | EXP | | 6480464 | CTD | Carbon Tetrachloride affects the localization of NFE2L2 protein | PMID:24975872 | Nfe2l2 | decreases expression | EXP | | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA; Carbon Tetrachloride results in decreased expression of NFE2L2 protein | PMID:17202758 PMID:35236242 | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased expression of NFE2L2 protein | PMID:18081878 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | [Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA; [Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein; [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 protein; Carbon Tetrachloride results in decreased expression of and affects the localization of NFE2L2 protein; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of and affects the localization of NFE2L2 protein]; Ellagic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein]; puerarin inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein] | PMID:24293383 PMID:24975872 PMID:28935427 PMID:31168027 PMID:35236242 | Nfe2l2 | affects localization | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride affects the localization of NFE2L2 protein | PMID:23341968 | Nfe2l2 | decreases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA; Carbon Tetrachloride results in decreased expression of NFE2L2 protein | PMID:25471833 PMID:29964319 PMID:37573684 PMID:37894611 | Nfe2l2 | increases activity | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in increased activity of NFE2L2 protein | PMID:30203046 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of NFE2L2 protein | PMID:32234387 | Nfe2l2 | increases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of NFE2L2 mRNA; Carbon Tetrachloride results in increased expression of NFE2L2 protein | PMID:21725986 PMID:22902988 PMID:31919559 PMID:32234387 | Nfe2l2 | increases localization | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in increased localization of NFE2L2 protein | PMID:18078705 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | [2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 protein; [AK-1 compound co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 mRNA; [AK-1 compound co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 protein; [Carbon Tetrachloride co-treated with AK-1 compound] results in increased expression of NFE2L2 mRNA; [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of NFE2L2 mRNA; [Glycyrrhetinic Acid results in increased expression of NFE2L2] which results in decreased susceptibility to Carbon Tetrachloride; alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA]; Carbon Tetrachloride affects the reaction [NFE2L2 protein affects the expression of CHRM4 protein]; Carbon Tetrachloride affects the reaction [NFE2L2 protein affects the expression of HMOX1 protein]; Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA]; gentian root extract inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA]; gentian root extract inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]; ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]; Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Carbon Tetrachloride results in increased expression of CHRM3 protein]; NFE2L2 protein affects the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]]; NFE2L2 protein affects the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA]]; Quercetin inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA]; Quercetin promotes the reaction [Carbon Tetrachloride results in increased expression of NFE2L2 protein]; Rutin promotes the reaction [Carbon Tetrachloride results in increased expression of NFE2L2 protein]; sulforaphane inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]; Tretinoin inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein]]; Tretinoin promotes the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 protein] | PMID:22902988 PMID:23341968 PMID:25471833 PMID:26443840 PMID:27477297 PMID:29964319 PMID:30517762 PMID:32063085 PMID:32234387 PMID:37573684 PMID:37894611 | | ||||||||||||||||||||||
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