GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | decreases expression | EXP | | 6480464 | CTD | Glucose results in decreased expression of NFE2L2 mRNA; Glucose results in decreased expression of NFE2L2 protein | PMID:21818840 PMID:23770986 PMID:31639451 PMID:35243728 | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of NFE2L2 mRNA; Glucose results in increased expression of NFE2L2 protein | PMID:29211853 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NFE2L2 protein; [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and affects the localization of NFE2L2 protein; diallyl trisulfide promotes the reaction [Glucose results in increased expression of and affects the localization of NFE2L2 protein]; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and affects the localization of NFE2L2 protein]; Glucose results in increased expression of and affects the localization of NFE2L2 protein; GSK3B protein inhibits the reaction [MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NFE2L2 protein]]; Inositol inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]; KEAP1 protein inhibits the reaction [diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and affects the localization of NFE2L2 protein]]; MIR135A mRNA inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [diallyl trisulfide inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; NFE2L2 protein affects the reaction [Exenatide inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; NFE2L2 protein affects the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; NFE2L2 protein affects the reaction [Glucose results in decreased expression of ACE2 mRNA]; NFE2L2 protein affects the reaction [Glucose results in decreased expression of MAS1 mRNA]; NFE2L2 protein affects the reaction [Glucose results in increased expression of ACE mRNA]; NFE2L2 protein affects the reaction [Glucose results in increased expression of AGT mRNA]; NFE2L2 protein affects the reaction [Glucose results in increased expression of NQO1 mRNA]; NFE2L2 protein mutant form affects the reaction [plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; NFE2L2 protein promotes the reaction [diallyl trisulfide inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP3 protein modified form]]; NFE2L2 protein promotes the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP3 protein modified form]]; NFE2L2 protein promotes the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PARP1 protein modified form]]; NFE2L2 protein promotes the reaction [diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of KEAP1 protein]]; NFE2L2 protein promotes the reaction [diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and affects the localization of NFE2L2 protein]]; oltipraz inhibits the reaction [trigonelline inhibits the reaction [Glucose results in increased expression of NFE2L2 protein]]; Quercetin inhibits the reaction [Glucose results in decreased expression of NFE2L2 mRNA]; Quercetin inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]; SRT1720 inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]; trigonelline inhibits the reaction [Glucose results in increased expression of NFE2L2 protein] | PMID:20028456 PMID:23453443 PMID:23770986 PMID:25896937 PMID:27939242 PMID:29211853 PMID:29719095 PMID:31639451 PMID:33359794 PMID:35191607 PMID:35243728 | Nfe2l2 | affects localization | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Glucose affects the localization of NFE2L2 protein | PMID:33270355 | Nfe2l2 | affects response to substance | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | NFE2L2 protein affects the susceptibility to Glucose | PMID:20086057 | Nfe2l2 | decreases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Glucose results in decreased expression of NFE2L2 mRNA; Glucose results in decreased expression of NFE2L2 protein | PMID:21333731 PMID:32602595 PMID:33962019 PMID:37586544 PMID:38000455 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Glucose deficiency results in increased expression of NFE2L2 mRNA; Glucose deficiency results in increased expression of NFE2L2 protein; Glucose results in increased expression of NFE2L2; Glucose results in increased expression of NFE2L2 mRNA; Glucose results in increased expression of NFE2L2 protein | PMID:20103708 PMID:21333731 PMID:29649567 PMID:33838154 | Nfe2l2 | increases localization | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Glucose deficiency results in increased localization of NFE2L2 protein | PMID:17928392 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Rosiglitazone inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]]; [Oxygen co-treated with Glucose] inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NFE2L2 protein]; [Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NFE2L2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Glucose results in increased expression of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; Particulate Matter inhibits the reaction [[Oxygen co-treated with Glucose] inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NFE2L2 protein]]; Phytic Acid inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]; Rosiglitazone inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]; solanesol inhibits the reaction [Glucose results in decreased expression of NFE2L2 mRNA]; solanesol inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]; spiraeoside inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]; Vehicle Emissions inhibits the reaction [[Oxygen co-treated with Glucose] inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of NFE2L2 protein]] | PMID:21333731 PMID:23954465 PMID:28400208 PMID:32602595 PMID:33838154 PMID:37586544 PMID:38000455 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [SMARCA4A protein affects the reaction [Glucose affects the localization of NFE2L2 protein]]; [NFE2L2 protein binds to TXNIP promoter] inhibits the reaction [Glucose results in increased expression of TXNIP mRNA]; [NFE2L2 protein co-treated with KEAP1 protein] affects the abundance of Glucose; [NFE2L2 protein mutant form co-treated with Streptozocin] results in increased abundance of Glucose; NFE2L2 mutant form inhibits the reaction [Glucose deficiency promotes the reaction [Simvastatin results in increased expression of HMOX1 mRNA]]; NFE2L2 protein affects the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of FN1 mRNA]]; NFE2L2 protein inhibits the reaction [Glucose results in increased expression of TXNIP mRNA]; SMARCA4A protein affects the reaction [Glucose affects the localization of NFE2L2 protein] | PMID:17928392 PMID:20086057 PMID:22869588 PMID:23017736 PMID:33270355 | | ||||||||||||||||||||||
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