Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects expressionEXP 6480464CTDEstradiol affects the expression of NFE2L2 mRNA; Estradiol affects the expression of NFE2L2 proteinPMID:22389237 PMID:24777823
Nfe2l2affects localizationEXP 6480464CTDEstradiol affects the localization of NFE2L2 proteinPMID:23027624
Nfe2l2decreases expressionEXP 6480464CTDEstradiol results in decreased expression of NFE2L2 mRNA; Estradiol results in decreased expression of NFE2L2 proteinPMID:23027624 PMID:23492819 PMID:24894866
Nfe2l2multiple interactionsEXP 6480464CTD[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of NFE2L2 protein]; Ascorbic Acid inhibits the reaction [Estradiol affects the localization of NFE2L2 protein]; Ascorbic Acid inhibits the reaction [Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]]; Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of NFE2L2 mRNA]; Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of NFE2L2 protein]; Butylated Hydroxyanisole inhibits the reaction [Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]]; Estradiol affects the reaction [Paraquat affects the expression of NFE2L2 protein]; Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]; Resveratrol inhibits the reaction [Estradiol results in decreased expression of NFE2L2 mRNA]; Resveratrol inhibits the reaction [Estradiol results in decreased expression of NFE2L2 protein]PMID:22389237 PMID:23027624 PMID:23492819 PMID:24894866 PMID:31715309
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDEstradiol results in decreased expression of NFE2L2 mRNA; Estradiol results in decreased expression of NFE2L2 proteinPMID:23492819 PMID:23583297 PMID:25130429 PMID:28960787
Nfe2l2increases activityISONfe2l2 (Mus musculus)6480464CTDEstradiol results in increased activity of NFE2L2 proteinPMID:30114225
Nfe2l2increases methylationISONFE2L2 (Homo sapiens)6480464CTDEstradiol results in increased methylation of NFE2L2 promoterPMID:24894866
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDAscorbic Acid inhibits the reaction [Estradiol results in decreased expression of NFE2L2 mRNA]; Ascorbic Acid inhibits the reaction [Estradiol results in decreased expression of NFE2L2 protein]; resveratrol inhibits the reaction [Estradiol results in decreased expression of NFE2L2 mRNA]; resveratrol inhibits the reaction [Estradiol results in decreased expression of NFE2L2 protein]; resveratrol inhibits the reaction [Estradiol results in increased methylation of NFE2L2 promoter]PMID:23492819 PMID:24894866 PMID:25130429
Go Back to source page   Continue to Ontology report