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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of NFE2L2 proteinPMID:26497626 PMID:37148149
Nfe2l2increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of NFE2L2 proteinPMID:22610192 PMID:28881715
Nfe2l2multiple interactionsEXP 6480464CTD[Dimethyl Sulfoxide co-treated with Resveratrol] inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]; gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]PMID:22610192 PMID:26497626 PMID:28881715 PMID:37148149
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of NFE2L2 proteinPMID:26497626 PMID:36135333 PMID:37436358
Nfe2l2decreases expressionISONfe2l2 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of NFE2L2 mRNA; Lipopolysaccharides results in decreased expression of NFE2L2 proteinPMID:26363199 PMID:36169195 PMID:36807594 PMID:37269934 PMID:37436358
Nfe2l2increases activityISONfe2l2 (Mus musculus)6480464CTDLipopolysaccharides results in increased activity of NFE2L2 proteinPMID:30114225 PMID:30203046
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of NFE2L2 proteinPMID:17959236
Nfe2l2increases expressionISONfe2l2 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of NFE2L2 proteinPMID:26505893 PMID:30200963 PMID:32187984
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] affects the localization of NFE2L2 protein; [Lipopolysaccharides co-treated with IFNG protein] promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NFE2L2 mRNA]; [Lipopolysaccharides co-treated with Resveratrol] results in decreased expression of NFE2L2 mRNA; [Lipopolysaccharides co-treated with Resveratrol] results in increased expression of NFE2L2 protein; Acetylcysteine inhibits the reaction [Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]; gingerenone A inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]; Lipopolysaccharides promotes the reaction [nickel chloride results in increased expression of NFE2L2 protein]; Luteolin promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] affects the localization of NFE2L2 protein]; Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [Lipopolysaccharides results in decreased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]]; NFE2L2 protein affects the reaction [Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; NFE2L2 protein affects the reaction [sulforaphane inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; NFE2L2 protein affects the reaction [Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]]; NFE2L2 protein affects the reaction [Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; NFE2L2 protein promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of SESN2 protein]; PIK 75 inhibits the reaction [[Lipopolysaccharides co-treated with Resveratrol] results in increased expression of NFE2L2 protein]; SIRT1 protein affects the reaction [catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]]; sodium selenide inhibits the reaction [Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]PMID:16890772 PMID:17959236 PMID:18437699 PMID:25637945 PMID:26497626 PMID:26667767 PMID:30768972 PMID:34217685 PMID:36135333 PMID:37436358
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]]; [Lipopolysaccharides co-treated with cobaltiprotoporphyrin] results in increased expression of NFE2L2 protein; [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NFE2L2 mRNA; [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NFE2L2 protein; [Lipopolysaccharides co-treated with genipin] results in increased activity of NFE2L2 protein; [NFE2L2 protein results in increased expression of HMOX1] affects the reaction [alpha-viniferin results in decreased susceptibility to Lipopolysaccharides]; catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 mRNA]; formononetin inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]; Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and affects the localization of NFE2L2 protein; luteolin-7-O-glucuronide promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]; morroniside promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and affects the localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of FOXO1 protein]]; NFE2L2 protein affects the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; NFE2L2 protein affects the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]]; NFE2L2 protein affects the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; NFE2L2 protein affects the reaction [cobaltiprotoporphyrin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; NFE2L2 protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; NFE2L2 protein affects the reaction [salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; NFE2L2 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; NFE2L2 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; NFE2L2 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]; palmatine inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]; Plant Extracts promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NFE2L2 mRNA]; Plant Extracts promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NFE2L2 protein]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 mRNA]; Quercetin promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]; Saponins inhibits the reaction [Lipopolysaccharides results in decreased expression of NFE2L2 protein]; Silymarin promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NFE2L2 mRNA]; Silymarin promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NFE2L2 protein]PMID:21382476 PMID:23942037 PMID:24859013 PMID:24991814 PMID:25171655 PMID:26363199 PMID:26505893 PMID:30114225 PMID:30203046 PMID:30236599 PMID:32187984 PMID:34029560 PMID:36169195 PMID:36807594 PMID:37269934 PMID:37436358
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