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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:15368
Term: acrolein
Definition: An enal that is prop-2-ene with an oxo group at position 1.
Chemical ID: MESH:D000171
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects localizationEXP 6480464CTDAcrolein affects the localization of NFE2L2 proteinPMID:25145656
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDAcrolein affects the localization of NFE2L2 proteinPMID:12084617 PMID:18048804
Nfe2l2affects localizationISONfe2l2 (Mus musculus)6480464CTDAcrolein affects the localization of NFE2L2 proteinPMID:12763045
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTD[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to AcroleinPMID:19303893
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDAcrolein results in decreased expression of NFE2L2 proteinPMID:17197552 PMID:18258206
Nfe2l2decreases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 results in decreased susceptibility to AcroleinPMID:18367636
Nfe2l2increases activityISONFE2L2 (Homo sapiens)6480464CTDAcrolein results in increased activity of NFE2L2 proteinPMID:12084617
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDAcrolein results in increased expression of NFE2L2 mRNA; Acrolein results in increased expression of NFE2L2 proteinPMID:26862668 PMID:28109747
Nfe2l2increases expressionISONfe2l2 (Mus musculus)6480464CTDAcrolein results in increased expression of NFE2L2 proteinPMID:28482051 PMID:30608172
Nfe2l2increases response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 gene mutant form results in increased susceptibility to AcroleinPMID:19608619
Nfe2l2increases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 gene mutant form results in increased susceptibility to AcroleinPMID:27633142
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of NFE2L2 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of NFE2L2 mRNA; [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein]; lipoamide inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Curcumin analog results in decreased susceptibility to Acrolein]; NFE2L2 protein affects the reaction [Curcumin results in decreased susceptibility to Acrolein]; NFE2L2 protein promotes the reaction [Acrolein results in increased expression of HMOX1 mRNA]; PRKCD protein promotes the reaction [Acrolein affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [Acrolein affects the localization of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]PMID:17197552 PMID:18048804 PMID:18258206 PMID:19608619 PMID:23954767 PMID:32699268
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD1,2-dithiol-3-thione promotes the reaction [NFE2L2 results in decreased susceptibility to Acrolein]; [Ovalbumin co-treated with Acrolein] results in increased expression of NFE2L2 protein; Buthionine Sulfoximine affects the reaction [[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Acrolein]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Acrolein]]; NFE2L2 protein affects the reaction [[cafestol co-treated with kahweol] results in decreased susceptibility to Acrolein]; NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Acrolein]PMID:18028974 PMID:18367636 PMID:19303893 PMID:20932822 PMID:30608172
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