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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:78673
Term: cumene hydroperoxide
Definition: A peroxol that is cumene in which the alpha-hydrogen is replaced by a hydroperoxy group.
Chemical ID: MESH:C007164
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDcumene hydroperoxide results in increased expression of PTGS2 proteinPMID:14972014
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD[cumene hydroperoxide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [cumene hydroperoxide results in increased expression of PTGS2 protein]PMID:14972014
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