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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:41072
Term: 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Definition: An indole that has formula C25H24N4O2.
Chemical ID: MESH:C070515
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2multiple interactionsEXP 6480464CTDbisindolylmaleimide I inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; bisindolylmaleimide I inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]PMID:17084486 PMID:21262218
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTDbisindolylmaleimide I inhibits the reaction [Aflatoxin B1 results in increased expression of PTGS2 protein]; bisindolylmaleimide I inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; bisindolylmaleimide I inhibits the reaction [NCX 4040 results in increased expression of PTGS2 protein]PMID:19084589 PMID:19576865 PMID:27818125
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